Force-Coded Strategy for the Simultaneous Detection of Multiple Tumor-Related Proteins

Mengxue Sun, Pan Lu, Chanchan Yu, Feng Feng, Qilong Li, Jinxiu Zhan, Min Xu, Yajing Liu, and Li Yao

 

    Multiplexed simultaneous detection of various cancer markers is required for accurate diagnosis and treatment of early cancer. In this work, we present a force-coded strategy for the simultaneous detection of tumor-related proteins with tunable dynamic range via magnetic sensing. The multiplexing capability of this method is achieved by designing DNA devices that can recognize different biomarkers and code them with different binding forces measured by the force-induced remnant magnetization spectroscopy, which is not influenced by the color of the light and the solution. Moreover, the force-coded assay with high sensitivity and adjustable detection range is robust, which could be used for practical biological applications such as magnetic sensing, handheld miniaturized systems, and potential in vivo diagnosis.

 

 

文章链接：https://pubs.acs.org/doi/full/10.1021/acs.analchem.2c01014